NAD+ & GLP-1 Medications: The Powerful Combo for Energy, Metabolism & Weight Loss
- Maria Rising
- Feb 17
- 3 min read
If you’re using a GLP-1 medication like Tirzepatide (Mounjaro, Zepbound) or Semaglutide (Ozempic, Wegovy) for weight loss, you may have noticed changes in energy levels, metabolism, or muscle mass. One supplement that’s gaining attention for its potential to support GLP-1 users is NAD+ (Nicotinamide Adenine Dinucleotide).
This powerful coenzyme plays a vital role in cellular energy, metabolism, and longevity. But how can it benefit those on GLP-1 medications? Let’s dive into the science and why NAD+ could be the missing piece in your weight loss supplement routine.
What Is NAD+ & Why Is It Important?
NAD+ is a critical molecule found in every cell of the body. It’s responsible for:✔ Converting food into energy (ATP production) 🔋✔ Repairing damaged cells & reducing inflammation 🧬✔ Supporting fat metabolism & insulin sensitivity 🔥✔ Activating sirtuins, longevity-related proteins 🧑🔬
As we age, NAD+ levels naturally decline, leading to slower metabolism, increased fatigue, and reduced cellular repair. This is why many experts recommend NAD+ supplementation to support energy, fat burning, and overall health.
How NAD+ Supports GLP-1 Users (Tirzepatide & Semaglutide)
Many people experience fatigue, muscle loss, or metabolic slowdowns while using GLP-1 medications for weight loss. Adding NAD+ to your routine may help counteract these effects.
1️⃣ Combats GLP-1 Fatigue & Low Energy
GLP-1s slow digestion & suppress appetite, which can lead to lower energy availability.
NAD+ increases mitochondrial function, helping the body produce more energy (ATP) even in a calorie deficit.
2️⃣ Boosts Metabolism & Fat Burning
GLP-1s improve insulin sensitivity, but NAD+ enhances fat oxidation.
Studies show NAD+ activates sirtuins, which play a role in breaking down stored fat.
3️⃣ Protects Muscle Mass During Weight Loss
Rapid weight loss from GLP-1s can lead to muscle loss if protein intake is too low.
NAD+ supports muscle preservation by fueling cellular repair & reducing oxidative stress.
4️⃣ Reduces Inflammation & Detoxifies Fat Loss Byproducts
When you burn fat, stored toxins are released into the bloodstream.
NAD+ supports liver detoxification and reduces oxidative stress, protecting against metabolic slowdown.
Best NAD+ Supplements for GLP-1 Users
If you’re considering adding NAD+ to your weight loss supplement stack, here are the best options:
IV Infusion (100% Usable in Body) —
Find a Local Wellness Spa That Offers Influsions and Call and Schedule
Some even can come to your home or work — like my local spot ThrIV Bio in East Lansing, MI!
Liposomal Patches (50–70% Usable in Body) - (absorbed through skin)(absorbed through skin)
Kind Patches are my favorite! I also use their Energy Patches too (lots of B Vitamins! Click HERE for 10% off with my link!
Final Thoughts:
Should You Take NAD+ With GLP-1s?
✅ If you’re feeling fatigued, experiencing metabolic slowdown, or concerned about muscle loss while on GLP-1 medications, NAD+ could be a valuable addition to your weight loss supplement routine.
By supporting energy production, fat burning, and cellular repair, NAD+ may help enhance the effects of GLP-1swhile reducing unwanted side effects.
💬 Have you tried NAD+ while on a GLP-1? Share your experience in the comments!
Ready to Take Your GLP-1 Journey to the Next Level?
👉 Check out my full supplement guide at www.MariaRising.com/TirzepatideTales!
🚀 Follow for more: @TirzepatideTales on all socials